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phenobarbital raises toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers may perhaps raise the metabolism of ifosfamide to its Energetic alkylating metabolites.This system is most likely from the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenoba